NAMED LECTURES
FEBS Lecturer


Dominique Soldati-Favre
University of Geneva
​
Switzerland
​
Functional and Computational Genomics Reveal Unprecedented Versatility in Stage-Specific Toxoplasma gondii Metabolism
​
PLENARY SPEAKERS

Balbir Singh
University Malaysia Sarawak
​
Malaysia
​
Plasmodium Biology

Leann Tilley
University of Melbourne
​
Australia
​
Plasmodium Therapeutics

Noburo Mizushima
University of Tokyo
​
Japan
​
Autophagy
SYMPOSIA SPEAKERS

Christian Doerig
Monash University
​
Australia
​
Protein phosphorylation
& malaria

Gong Cheng
Tsinghua University
​
China
​
immuno–pathogenesis of mosquito-borne flaviviral diseases

Souvik Bhattacharjee
Jawaharlal Nehru University
​
India
​
Artemisinin resistance
FEBS Lecturer
​

Dominique Soldati-Favre
University of Geneva
Switzerland
​
FUNCTIONAL AND COMPUTATIONAL GENOMICS REVEAL UNPRECEDENTED VERSATILITY IN STAGE-SPECIFIC TOXOPLASMA GONDII METABOLISM
Tumor-infiltrating lymphocytes (TIL) are associated with survival in virtually every human cancer, but the mechanisms by which they confer protective immunity remain incompletely understood. Focusing on ovarian cancer, our group applies genomic and molecular pathology approaches to define the mechanisms by which the human immune system responds to the evolving tumor genome over space and time. We find that optimal anti-tumor immunity involves interactions between T cells and antibody-producing B cells in the tumor microenvironment. We have evidence that T cell clones track tumor clones over space and time and apply selective pressure that leads to reduced tumor clone diversity and progressive loss of immune recognition through several mechanisms. Our findings suggest new strategies to overcome these challenges through T cell engineering and other approaches. Toward this goal, I will discuss our cancer centre's new clinical trials program focused on T cell engineering strategies for gynecological and lymphoid cancers.